Aleksandar Obradovic Lab

Research

Our research focus is on developing computational tools for analysis of single-cell RNA sequencing and multimodal data types and applying these tools for improved understanding of tumor immunotherapy resistance mechanisms. With multiple mechanisms of treatment resistance present to varying degreees across tumor types and across patients, it is critical to understand tumor immune interactions within the microenvironment of solid tumors and develop a rational approach to combination therapy in treatment-resistant individuals.

2026

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Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO
Brian W. Labadie, Aleksandar Obradovic, Alexander G. Raufi, Urszula N. Wasko, Lorenzo Tomassoni, Liner Ge, Michael May, Manan Vij, Li Li, Isabelle Ross, Sarah S. Sedycius, Naomi Sender, Nickolas Dreher, Linda Wu, Sinan Abuzaid, Alina Iuga, Parin Shah, Julia D. Wulfkuhle, Susan Bates, Winston Wong, Ilenia Pellicciotta, Alex K. Lyashchenko, Howard Safran, Benjamin Izar, Emanuel F. Petricoin, Serge Cremers, Aik Choon Tan, Shing Lee, Andrea Califano, Kenneth P. Olive, Gulam A. Manji
JCO Precision Oncology  ·  01 Jun 2026
tumor immunology
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Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO
Brian W. Labadie, Aleksandar Obradovic, Alexander G. Raufi, Urszula N. Wasko, Lorenzo Tomassoni, Liner Ge, Michael May, Manan Vij, Li Li, Isabelle Ross, Sarah S. Sedycius, Naomi Sender, Nickolas Dreher, Linda Wu, Sinan Abuzaid, Alina Iuga, Parin Shah, Julia D. Wulfkuhle, Susan Bates, Winston Wong, Ilenia Pellicciotta, Alex K. Lyashchenko, Howard Safran, Benjamin Izar, Emanuel F. Petricoin, Serge Cremers, Aik Choon Tan, Shing Lee, Andrea Califano, Kenneth P. Olive, Gulam A. Manji
JCO Precision Oncology  ·  01 Jun 2026
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Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states
Ester Calvo Fernández, Lorenzo Tomassoni, Xu Zhang, Junqiang Wang, Aleksandar Obradovic, Pasquale Laise, Aaron T. Griffin, Lukas Vlahos, Hanna E. Minns, Diana V. Morales, Christian Simmons, Matthew Gallitto, Hong-Jian Wei, Timothy J. Martins, Pamela S. Becker, John R. Crawford, Theophilos Tzaridis, Robert J. Wechsler-Reya, James Garvin, Robyn D. Gartrell, Luca Szalontay, Stergios Zacharoulis, Cheng-Chia Wu, Zhiguo Zhang, Andrea Califano, Jovana Pavisic
Nature Genetics  ·  22 Apr 2026
tumor immunology
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Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states
Ester Calvo Fernández, Lorenzo Tomassoni, Xu Zhang, Junqiang Wang, Aleksandar Obradovic, Pasquale Laise, Aaron T. Griffin, Lukas Vlahos, Hanna E. Minns, Diana V. Morales, Christian Simmons, Matthew Gallitto, Hong-Jian Wei, Timothy J. Martins, Pamela S. Becker, John R. Crawford, Theophilos Tzaridis, Robert J. Wechsler-Reya, James Garvin, Robyn D. Gartrell, Luca Szalontay, Stergios Zacharoulis, Cheng-Chia Wu, Zhiguo Zhang, Andrea Califano, Jovana Pavisic
Nature Genetics  ·  22 Apr 2026
tumor immunology
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Abstract CT017: Neoadjuvant IL-1β and PD-1 inhibition in localized clear-cell renal cell carcinoma: Clinical and correlative analyses of the phase 1b SPARC-1 trial
Patrick J. McCann, Aleksandar Obradovic, Casey R. Ager, David H. Aggen, Catherine S. Spina, Chelsea L. Rahiman, Kaitlyn R. Campbell, Caroline Laplaca, Peyton C. Johnston, Amanda Kim, Katherine Gomez, Kriti Bagri Manjrekar, Mark N. Stein, Charles G. Drake, Karie Runcie, Matthew Dallos
Cancer Research  ·  17 Apr 2026
tumor immunology
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Abstract 4938: Elucidation and pharmacologic targeting of master regulator proteins representing mechanistic determinants of macrophage state and immunoevasive potential
Gaetano Viscido, Mikko Turunen, Zhouzerui Liu, Justyn Chang, Meghna S. Raman, Leo B. Dupire, Hanrui Zhang, Tim Olsen, Jeremy Worley, Aleksandar Obradovic, Andrea Califano
Cancer Research  ·  03 Apr 2026
tumor immunology
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Abstract 7419: Comprehensive profiling of primary and metastatic prostate tumors reveals distinct tumor and fibroblast cell states associated with androgen resistance
Aleksandar Obradovic, Kwangmin Yoo, Chang Liu, Patrick McCann, Casey R. Ager, Matthew C. Dallos, Samir Zaidi
Cancer Research  ·  03 Apr 2026
tumor immunology
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Neoadjuvant Fc-enhanced anti-CTLA-4 targets Tregs to augment androgen deprivation in high-risk prostate cancer: A randomized phase I trial
Casey R. Ager, Aleksandar Obradovic, Patrick McCann, Matthew Chaimowitz, Alexander L.E. Wang, Neha Shaikh, Parin Shah, Samuel S. Pan, Caroline J. Laplaca, Renu K. Virk, Jessica C. Hill, Collin Jugler, Grace DeFranco, Nilika Bhattacharya, Kade R. Copple, Phuong Nguyen, Howard I. Scher, Guarionex Joel DeCastro, Christopher B. Anderson, James M. McKiernan, Catherine S. Spina, Mark N. Stein, Karie Runcie, Charles G. Drake, Andrea Califano, Matthew C. Dallos
Cell Reports Medicine  ·  17 Mar 2026
tumor immunology
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Physician-scientist hiring practices at US universities before and after the COVID-19 pandemic
Evan Noch, Aleksandar Obradovic, Snigdha Jain, Jennifer M Kwan
openRxiv  ·  12 Mar 2026

2025

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Supplementary Table 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Table 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Figures from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Data 6 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Data 5 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Data 4 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Data 3 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Data 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Supplementary Data 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  11 Dec 2025
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Ruxolitinib increases immunogenicity and primes the tumor microenvironment for immune checkpoint blockade in 9p24.1 amplified lymphomas
Seda Tolu, Ted Piorczynski, Manuel Pazos, Brian Estrella, Aleksandar Obradovic, Hua-Jay Cherng, Barbara Pro, Jennifer Amengual
Blood  ·  03 Nov 2025
tumor immunology
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Abstract 7479: Single-cell OncoTreat: Novel therapeutic candidates by high resolution inference and validation of drug sensitivities in heterogeneous cholangiocarcinoma tumors
Aleksandar Obradovic, Lorenzo Tomassoni, Daoqi You, Charles Drake, Filemon Dela Cruz, Andrew Kung, Andrea Califano
Cancer Research  ·  21 Apr 2025
tumor immunology
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Abstract 3442: Multi-omics comparison of early vs late-onset colorectal cancer reveals distinct tumor phenotype of early-onset patients
David Cohen, Aleksandar Obradovic, Luka Jovanovic, Soobeom Lee, Dechokyab De, Casidhe-Nicole Bethancourt, Caitlin Rogers, Yosuke Mitani, Tianxia Li, Viktoria Jakubikova, Yoanna Pumpalova, Beatrice Dionigi, Sanja Vickovic, Joel Gabre
Cancer Research  ·  21 Apr 2025
tumor immunology
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Fc-enhanced anti-CTLA-4 depletes tumor-infiltrating regulatory T cells to augment immune effects of androgen ablation in high-risk prostate cancer
Casey R. Ager, Aleksandar Obradovic, Patrick McCann, Matthew Chaimowitz, Alexander L. E. Wang, Neha Shaikh, Parin Shah, Samuel S. Pan, Caroline J. Laplaca, Renu K. Virk, Jessica C. Hill, Collin Jugler, Grace DeFranco, Nilika Bhattacharya, Kade R. Copple, Howard I. Scher, Guarionex Joel DeCastro, Christopher B. Anderson, James M. McKiernan, Catherine S. Spina, Mark N. Stein, Karie Runcie, Charles G. Drake, Andrea Califano, Matthew C. Dallos
openRxiv  ·  31 Mar 2025
tumor immunology
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Abstract B028: Multimodal approach to characterization of metabolism and immune modulation with insights from spatial metabolomics and transcriptomics
Chelsea L. Rahiman, Roberto Ribas, Manan Vij, Julia An, Patrick J. McCann, Jason Cham, Chang Liu, Parin Shah, Rosa Martin, Ariel Chen, Simon Cheng, Aleksandar Z. Obradovic, Ramon C. Sun, Catherine S. Spina
Clinical Cancer Research  ·  26 Jan 2025
tumor immunology

2024

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Supplemental Figure S6 from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Supplemental Figure S5 from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Supplemental Figure S4 from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Supplemental Figure S3 from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Supplemental Figure S2 from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Supplemental Figure S1 from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Data from Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
American Association for Cancer Research (AACR)  ·  15 Nov 2024
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Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
Clinical Cancer Research  ·  13 Sep 2024
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Fc-enhanced anti-CTLA-4 depletes tumor-infiltrating regulatory T cells to augment immune effects of androgen ablation in high-risk prostate cancer
Casey R. Ager, Aleksandar Obradovic, Patrick McCann, Matthew Chaimowitz, Alexander L. E. Wang, Neha Shaikh, Parin Shah, Samuel S. Pan, Caroline J. Laplaca, Renu K. Virk, Jessica C. Hill, Collin Jugler, Grace DeFranco, Nilika Bhattacharya, Kade R. Copple, Howard I. Scher, Guarionex Joel DeCastro, Christopher B. Anderson, James M. McKiernan, Catherine S. Spina, Mark N. Stein, Karie Runcie, Charles G. Drake, Andrea Califano, Matthew C. Dallos
openRxiv  ·  11 Sep 2024
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Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen–targeted therapies
Samir Zaidi, Jooyoung Park, Joseph M. Chan, Martine P. Roudier, Jimmy L. Zhao, Anuradha Gopalan, Kristine M. Wadosky, Radhika A. Patel, Erolcan Sayar, Wouter R. Karthaus, D. Henry Kates, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Linas Mazutis, Ronan Chaligné, Aleksandar Obradovic, Irina Linkov, Afsar Barlas, Achim A. Jungbluth, Natasha Rekhtman, Joachim Silber, Katia Manova-Todorova, Philip A. Watson, Lawrence D. True, Colm Morrissey, Howard I. Scher, Dana E. Rathkopf, Michael J. Morris, David W. Goodrich, Jungmin Choi, Peter S. Nelson, Michael C. Haffner, Charles L. Sawyers
Proceedings of the National Academy of Sciences  ·  09 Jul 2024
tumor immunology
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Abstract 6516: Single-cell protein activity inference reveals lymphocytic immune infiltration in diffuse intrinsic pontine glioma induced by focused ultrasound
Erin White, Hong-Jian Wei, Ester Calvo Fernández, Hanna Minns, Jovana Pavisic, Robyn Gartrell, Cheng-Chia Wu, Andrea Califano, Aleksandar Obradovic
Cancer Research  ·  22 Mar 2024
tumor immunology
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Abstract 1127: Single cell network-based analyses reveal dose-dependent increase in myeloid suppressive cell sub-populations in response to radiation therapy
Aparna Krishnan, Shruti Bansal, Samanta Sarti, Michael D. Kissner, Charles Karan, Andrea Califano, Aleksandar Z. Obradovic, Catherine S. Spina
Cancer Research  ·  22 Mar 2024
tumor immunology
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Abstract 5460: Discovery and validation of effective combination therapies targeting cell state-specific master regulator vulnerabilities by network-based protein activity inference in diffuse midline glioma
Ester Calvo Fernandez, Lorenzo Tomassoni, Xu Zhang, Aleksandar Obradovic, Pasquale Laise, Aaron T. Griffin, Lukas Vlahos, Junqiang Wang, Hanna E. Minns, Diana V. Morales, Christian Simmons, Matthew Gallito, Hong-Jian Wei, Zhiguo Zhang, Robyn Gartrell, Luca Szalontay, Stergios Zacharoulis, Cheng-Chia Wu, Andrea Califano, Jovana Pavisic
Cancer Research  ·  22 Mar 2024
tumor immunology
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Dynamic establishment of recipient resident memory T cell repertoire after human intestinal transplantation
Wenyu Jiao, Mercedes Martinez, Constanza Bay Muntnich, Julien Zuber, Christopher Parks, Aleksandar Obradovic, Guangyao Tian, Zicheng Wang, Katherine D. Long, Elizabeth Waffarn, Kristjana Frangaj, Rebecca Jones, Alaka Gorur, Brittany Shonts, Kortney Rogers, Guoyue Lv, Monica Velasco, Shilpa Ravella, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Jianing Fu, Megan Sykes
eBioMedicine  ·  06 Mar 2024
transplant immunology
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Immunomodulatory response to neoadjuvant nivolumab in non-metastatic clear cell renal cell carcinoma
Nirmish Singla, Thomas R. Nirschl, Aleksandar Z. Obradovic, Eugene Shenderov, Kara Lombardo, Xiaopu Liu, Alice Pons, Jelani C. Zarif, Steven P. Rowe, Bruce J. Trock, Hans J. Hammers, Trinity J. Bivalacqua, Phillip M. Pierorazio, Julie S. Deutsch, Tamara L. Lotan, Janis M. Taube, Yasser M. A. Ged, Michael A. Gorin, Mohamad E. Allaf, Charles G. Drake
Scientific Reports  ·  17 Jan 2024
tumor immunology

2023

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Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
Jianing Fu, Zicheng Wang, Mercedes Martinez, Aleksandar Obradovic, Wenyu Jiao, Kristjana Frangaj, Rebecca Jones, Xinzheng V. Guo, Ya Zhang, Wan-I Kuo, Huaibin M. Ko, Alina Iuga, Constanza Bay Muntnich, Adriana Prada Rey, Kortney Rogers, Julien Zuber, Wenji Ma, Michelle Miron, Donna L. Farber, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Megan Sykes
Journal of Experimental Medicine  ·  13 Dec 2023
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Characterization of gene expression and biological pathways in Wilms tumor
Claire D. Gerall, Aleksandar Z. Obradovic, Madison C. Betcher, Larisa Debelenko, Alice Lee, Matthew C. Dallos, Erica M. Fallon
Journal of Pediatric Surgery Open  ·  03 Dec 2023
tumor immunology
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KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Casey R Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Somnath Tagore, Aleksandar Obradovic, Collin Jugler, Meri Rogava, Johannes C Melms, Patrick McCann, Catherine Spina, Charles G Drake, Matthew C Dallos, Benjamin Izar
Journal for ImmunoTherapy of Cancer  ·  01 Sep 2023
tumor immunology
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Supplementary Table 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Table 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Table 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Table 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Figures from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Figures from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 6 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 6 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 5 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 5 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 4 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 4 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 3 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 3 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Supplementary Data 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Data from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Data from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  04 May 2023
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Systematic elucidation and pharmacological targeting of tumor-infiltrating regulatory T cell master regulators
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Supplementary Table 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Table 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Table 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Table 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Figures from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Figures from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 6 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 6 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 5 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 5 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 4 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 4 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 3 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 3 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 2 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Supplementary Data 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Data from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
American Association for Cancer Research (AACR)  ·  17 Apr 2023
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Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Joshua H. Choe, Tatsuya Kawase, An Xu, Asja Guzman, Aleksandar Z. Obradovic, Ana Maria Low-Calle, Bita Alaghebandan, Ananya Raghavan, Kaitlin Long, Paul M. Hwang, Joshua D. Schiffman, Yan Zhu, Ruiying Zhao, Dung-Fang Lee, Chen Katz, Carol Prives
Cancer Discovery  ·  17 Apr 2023
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Precision immunotherapy
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KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Casey R. Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Aleksandar Obradovic, Meri Rogava, Johannes C. Melms, Patrick McCann, Catherine Spina, Charles G. Drake, Matthew C. Dallos, Benjamin Izar
Cold Spring Harbor Laboratory  ·  02 Jan 2023
tumor immunology

2022

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tumor immunologysystems biology
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Single-Cell RNAseq Analysis Reveals Robust, Anti-PD-1-Mediated Increase of Immune Infiltrate in Metastatic Castration-Sensitive Prostate Cancer
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Cold Spring Harbor Laboratory  ·  02 Mar 2022
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Case Study of Single-cell Protein Activity Based Drug Prediction for Precision Treatment of Cholangiocarcinoma
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Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators
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openRxiv  ·  23 Feb 2022
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Cold Spring Harbor Laboratory  ·  25 Jan 2022
systems biology

2021

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BCG invokes superior STING ‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer
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Integrated analysis toolset for defining and tracking alloreactive T-cell clones after human solid organ and hematopoietic stem cell transplantation
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2020

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T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy
Marlena V. Habal, April M. I. Miller, Samhita Rao, Sijie Lin, Aleksandar Obradovic, Mohsen Khosravi‐Maharlooei, Sarah B. See, Poulomi Roy, Ronzon Shihab, Siu‐Hong Ho, Charles C. Marboe, Yoshifumi Naka, Koji Takeda, Susan Restaino, Arnold Han, Donna Mancini, Michael Givertz, Joren C. Madsen, Megan Sykes, Linda J. Addonizio, Maryjane A. Farr, Emmanuel Zorn
American Journal of Transplantation  ·  05 Oct 2020
transplant immunology
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T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer
Aleksandar Z. Obradovic, Matthew C. Dallos, Marianna L. Zahurak, Alan W. Partin, Edward M. Schaeffer, Ashley E. Ross, Mohamad E. Allaf, Thomas R. Nirschl, David Liu, Carolyn G. Chapman, Tanya O'Neal, Haiyi Cao, Jennifer N. Durham, Gunes Guner, Javier A. Baena-Del Valle, Onur Ertunc, Angelo M. De Marzo, Emmanuel S. Antonarakis, Charles G. Drake
Clinical Cancer Research  ·  01 Jul 2020
tumor immunology
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T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer
Aleksandar Z. Obradovic, Matthew C. Dallos, Marianna L. Zahurak, Alan W. Partin, Edward M. Schaeffer, Ashley E. Ross, Mohamad E. Allaf, Thomas R. Nirschl, David Liu, Carolyn G. Chapman, Tanya O'Neal, Haiyi Cao, Jennifer N. Durham, Gunes Guner, Javier A. Baena-Del Valle, Onur Ertunc, Angelo M. De Marzo, Emmanuel S. Antonarakis, Charles G. Drake
Clinical Cancer Research  ·  01 Jul 2020
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Deletion of donor-reactive T cell clones after human liver transplant
Thomas M. Savage, Brittany A. Shonts, Saiping Lau, Aleksandar Obradovic, Harlan Robins, Abraham Shaked, Yufeng Shen, Megan Sykes
American Journal of Transplantation  ·  01 Feb 2020
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Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro
Manuel A. Podestà, Christian Binder, Felix Sellberg, Susan DeWolf, Brittany Shonts, Siu-Hong Ho, Aleksandar Obradovic, Elizabeth Waffarn, Nichole Danzl, David Berglund, Megan Sykes
American Journal of Transplantation  ·  01 Jan 2020

2019

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Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
Wendy Mao, Ali Ghasemzadeh, Zachary T. Freeman, Aleksandar Obradovic, Matthew G. Chaimowitz, Thomas R. Nirschl, Emily McKiernan, Srinivasan Yegnasubramanian, Charles G. Drake
Journal for ImmunoTherapy of Cancer  ·  25 Oct 2019
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Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
Wendy Mao, Ali Ghasemzadeh, Zachary T. Freeman, Aleksandar Obradovic, Matthew G. Chaimowitz, Thomas R. Nirschl, Emily McKiernan, Srinivasan Yegnasubramanian, Charles G. Drake
Journal for ImmunoTherapy of Cancer  ·  01 Oct 2019
tumor immunology
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Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro
Manuel A. Podestà, Christian Binder, Felix Sellberg, Susan DeWolf, Brittany Shonts, Siu‐Hong Ho, Aleksandar Obradovic, Elizabeth Waffarn, Nichole Danzl, David Berglund, Megan Sykes
American Journal of Transplantation  ·  18 Jul 2019
transplant immunology
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Cross-reactive public TCR sequences undergo positive selection in the human thymic repertoire
Mohsen Khosravi-Maharlooei, Aleksandar Obradovic, Aditya Misra, Keshav Motwani, Markus Holzl, Howard R. Seay, Susan DeWolf, Grace Nauman, Nichole Danzl, Haowei Li, Siu-hong Ho, Robert Winchester, Yufeng Shen, Todd M. Brusko, Megan Sykes
Journal of Clinical Investigation  ·  13 May 2019
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Cross-reactive public TCR sequences undergo positive selection in the human thymic repertoire
Mohsen Khosravi-Maharlooei, Aleksandar Obradovic, Aditya Misra, Keshav Motwani, Markus Holzl, Howard R. Seay, Susan DeWolf, Grace Nauman, Nichole Danzl, Haowei Li, Siu-hong Ho, Robert Winchester, Yufeng Shen, Todd M. Brusko, Megan Sykes
Journal of Clinical Investigation  ·  28 Mar 2019
transplant immunologysystems biology
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Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool
Jianing Fu, Julien Zuber, Mercedes Martinez, Brittany Shonts, Aleksandar Obradovic, Hui Wang, Sai-ping Lau, Amy Xia, Elizabeth E. Waffarn, Kristjana Frangaj, Thomas M. Savage, Michael T. Simpson, Suxiao Yang, Xinzheng V. Guo, Michelle Miron, Takashi Senda, Kortney Rogers, Adeeb Rahman, Siu-hong Ho, Yufeng Shen, Adam Griesemer, Donna L. Farber, Tomoaki Kato, Megan Sykes
Cell Stem Cell  ·  07 Feb 2019
transplant immunology
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Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool
Jianing Fu, Julien Zuber, Mercedes Martinez, Brittany Shonts, Aleksandar Obradovic, Hui Wang, Sai-ping Lau, Amy Xia, Elizabeth E. Waffarn, Kristjana Frangaj, Thomas M. Savage, Michael T. Simpson, Suxiao Yang, Xinzheng V. Guo, Michelle Miron, Takashi Senda, Kortney Rogers, Adeeb Rahman, Siu-hong Ho, Yufeng Shen, Adam Griesemer, Donna L. Farber, Tomoaki Kato, Megan Sykes
Cell Stem Cell  ·  01 Feb 2019

2018

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Early expansion of donor-specific Tregs in tolerant kidney transplant recipients
Thomas M. Savage, Brittany A. Shonts, Aleksandar Obradovic, Susan Dewolf, Saiping Lau, Julien Zuber, Michael T. Simpson, Erik Berglund, Jianing Fu, Suxiao Yang, Siu-Hong Ho, Qizhi Tang, Laurence A. Turka, Yufeng Shen, Megan Sykes
JCI Insight  ·  15 Nov 2018
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Early expansion of donor-specific Tregs in tolerant kidney transplant recipients
Thomas M. Savage, Brittany A. Shonts, Aleksandar Obradovic, Susan Dewolf, Saiping Lau, Julien Zuber, Michael T. Simpson, Erik Berglund, Jianing Fu, Suxiao Yang, Siu-Hong Ho, Qizhi Tang, Laurence A. Turka, Yufeng Shen, Megan Sykes
JCI Insight  ·  01 Nov 2018
transplant immunology
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Quantifying size and diversity of the human T cell alloresponse
Susan DeWolf, Boris Grinshpun, Thomas Savage, Sai Ping Lau, Aleksandar Obradovic, Brittany Shonts, Suxiao Yang, Heather Morris, Julien Zuber, Robert Winchester, Megan Sykes, Yufeng Shen
JCI Insight  ·  09 Aug 2018
transplant immunologysystems biology
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Quantifying size and diversity of the human T cell alloresponse
Susan DeWolf, Boris Grinshpun, Thomas Savage, Sai Ping Lau, Aleksandar Obradovic, Brittany Shonts, Suxiao Yang, Heather Morris, Julien Zuber, Robert Winchester, Megan Sykes, Yufeng Shen
JCI Insight  ·  09 Aug 2018

2017

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Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney–Bone Marrow Transplantation to Induce Transplantation Tolerance
B. Sprangers, S. DeWolf, T.M. Savage, T. Morokata, A. Obradovic, S.A. LoCascio, B. Shonts, J. Zuber, S.P. Lau, R. Shah, H. Morris, V. Steshenko, E. Zorn, F.I. Preffer, S. Olek, D.M. Dombkowski, L.A. Turka, R. Colvin, R. Winchester, T. Kawai, M. Sykes
American Journal of Transplantation  ·  01 Aug 2017
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Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance
B. Sprangers, S. DeWolf, T. M. Savage, T. Morokata, A. Obradovic, S. A. LoCascio, B. Shonts, J. Zuber, S. P. Lau, R. Shah, H. Morris, V. Steshenko, E. Zorn, F. I. Preffer, S. Olek, D. M. Dombkowski, L. A. Turka, R. Colvin, R. Winchester, T. Kawai, M. Sykes
American Journal of Transplantation  ·  01 Mar 2017
transplant immunology

2016

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Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome
Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L. Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
Science Immunology  ·  21 Oct 2016
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Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome
Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L. Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
Science Immunology  ·  01 Oct 2016
transplant immunology
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Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome
Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
Science immunology  ·  01 Oct 2016

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Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer
Jessica E. Hawley, Aleksandar Z. Obradovic, Matthew C. Dallos, Emerson A. Lim, Karie Runcie, Casey R. Ager, James McKiernan, Christopher B. Anderson, Guarionex J. Decastro, Joshua Weintraub, Renu Virk, Israel Lowy, Jianhua Hu, Matthew G. Chaimowitz, Xinzheng V. Guo, Ya Zhang, Michael C. Haffner, Jeremy Worley, Mark N. Stein, Andrea Califano, Charles G. Drake
Cancer Cell  ·  [no date info]
tumor immunology
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Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
Jianing Fu, Zicheng Wang, Mercedes Martinez, Aleksandar Obradovic, Wenyu Jiao, Kristjana Frangaj, Rebecca Jones, Xinzheng V. Guo, Ya Zhang, Wan-I Kuo, Huaibin M. Ko, Alina Iuga, Constanza Bay Muntnich, Adriana Prada Rey, Kortney Rogers, Julien Zuber, Wenji Ma, Michelle Miron, Donna L. Farber, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Megan Sykes
Journal of Experimental Medicine  ·  [no date info]
transplant immunology
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Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
Clinical Cancer Research  ·  [no date info]
tumor immunology
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TMPO promotes cellular dissemination and metastasis in circulating tumor cells
Arianna Giacobbe, Aleksandar Z. Obradovic, Jinqiu Lu, Soonbum Park, Carlos Pedraz-Valdunciel, Giuseppe Nicolo’ Fanelli, Aunika Zheng, Jaime Y. Kim, Maya Stella Dixon, Jung Seung Nam, Florencia Picech, Caroline Laplaca, Renu K. Virk, Matteo Di Bernardo, Alexander Chui, Juan M. Arriaga, Stephanie Afari, Francisca Nunes de Almeida, Min Zou, Helen Garcia, Brian D. Robinson, Hongshan Guo, Shyamala Maheswaran, Daniel A. Haber, David T. Miyamoto, David M. Nanus, Scott T. Tagawa, Tian Zheng, Massimo Loda, Iok In Christine Chio, Michael Shen, Paraskevi Giannakakou, Andrea Califano, Peter A. Sims, Cory Abate-Shen
openRxiv  ·  [no date info]
tumor immunology