Aleksandar Obradovic Lab

Research

Our research focus is on developing computational tools for analysis of single-cell RNA sequencing and multimodal data types and applying these tools for improved understanding of tumor immunotherapy resistance mechanisms. With multiple mechanisms of treatment resistance present to varying degreees across tumor types and across patients, it is critical to understand tumor immune interactions within the microenvironment of solid tumors and develop a rational approach to combination therapy in treatment-resistant individuals.

2023

Aleksandar Obradovic, Casey Ager, Mikko Turunen, Thomas Nirschl, Mohsen Khosravi-Maharlooei, Alina Iuga, Christopher M. Jackson, Srinivasan Yegnasubramanian, Lorenzo Tomassoni, Ester Calvo Fernandez, Patrick McCann, Meri Rogava, Angelo M. DeMarzo, Christina M. Kochel, Mohamad Allaf, Trinity Bivalacqua, Michael Lim, Ronald Realubit, Charles Karan, Charles G. Drake, Andrea Califano
Cancer Cell  ·  27 Apr 2023
Aleksandar Obradovic
Science  ·  16 Feb 2023
Casey R. Ager, Mingxuan Zhang, Matthew Chaimowitz, Shruti Bansal, Aleksandar Obradovic, Meri Rogava, Johannes C. Melms, Patrick McCann, Catherine Spina, Charles G. Drake, Matthew C. Dallos, Benjamin Izar
Cold Spring Harbor Laboratory  ·  02 Jan 2023

2022

Christina Guo, Ines Figueiredo, Bora Gurel, Antje Neeb, George Seed, Mateus Crespo, Suzanne Carreira, Jan Rekowski, Lorenzo Buroni, Jon Welti, Denisa Bogdan, Lewis Gallagher, Adam Sharp, Maria D. Fenor de la Maza, Pasquale Rescigno, Daniel Westaby, Khobe Chandran, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Bianca Calì, Andrea Alimonti, Silvia Bressan, Alana H.T. Nguyen, Michael M. Shen, Jessica E. Hawley, Aleksandar Obradovic, Charles G. Drake, Claudia Bertan, Chloe Baker, Nina Tunariu, Wei Yuan, Johann S. de Bono
European Urology  ·  13 Sep 2022
Aleksandar Obradovic, Diana Graves, Michael Korrer, Yu Wang, Sohini Roy, Abdullah Naveed, Yaomin Xu, Adam Luginbuhl, Joseph Curry, Michael Gibson, Kamran Idrees, Paula Hurley, Peng Jiang, X. Shirley Liu, Ravindra Uppaluri, Charles G. Drake, Andrea Califano, Young J. Kim
Clinical Cancer Research  ·  15 May 2022
Jessica E. Hawley, Aleksandar Z. Obradovic, Matthew C. Dallos, Emerson A. Lim, Karie Runcie, Casey R. Ager, James McKiernan, Christopher B. Anderson, Joel Decastro, Joshua Weintraub, Renu Virk, Israel Lowy, Jianhua Hu, Matthew G. Chaimowitz, Xinzheng V. Guo, Ya Zhang, Jeremy Worley, Mark N. Stein, Andrea Califano, Charles G. Drake
Cold Spring Harbor Laboratory  ·  09 May 2022
Aleksandar Obradovic, Lorenzo Tomassoni, Daoqi Yu, Kristina Guillan, Katie Souto, Elise Fraser, Susan Bates, Charles G. Drake, Yvonne Saenger, Filemon Dela Cruz, Andrew Kung, Andrea Califano
Cold Spring Harbor Laboratory  ·  02 Mar 2022
Aleksandar Obradovic, Casey Ager, Mikko Turunen, Thomas Nirschl, Mohsen Khosravi-Maharlooei, Christopher Jackson, Vassan Yegnasubramanian, Angelo DeMarzo, Christina Kochel, Mohamad Allaf, Trinity Bivalacqua, Michael Lim, Charles Karan, Charles G. Drake, Andrea Califano
Cold Spring Harbor Laboratory  ·  23 Feb 2022
Aleksandar Obradovic, Lukas Vlahos, Pasquale Laise, Jeremy Worley, Xiangtian Tan, Alec Wang, Andrea Califano
Cold Spring Harbor Laboratory  ·  25 Jan 2022

2021

Kara A Lombardo, Aleksandar Obradovic, Alok Kumar Singh, James L Liu, Gregory Joice, Max Kates, William Bishai, David McConkey, Alcides Chaux, Marie‐Lisa Eich, M Katayoon Rezaei, George J Netto, Charles G Drake, Phuoc Tran, Andres Matoso, Trinity J Bivalacqua
The Journal of Pathology  ·  03 Nov 2021
Zoila A. Lopez-Bujanda, Michael C. Haffner, Matthew G. Chaimowitz, Nivedita Chowdhury, Nicholas J. Venturini, Radhika A. Patel, Aleksandar Obradovic, Corey S. Hansen, Joanna Jacków, Janielle P. Maynard, Karen S. Sfanos, Cory Abate-Shen, Charles J. Bieberich, Paula J. Hurley, Mark J. Selby, Alan J. Korman, Angela M. Christiano, Angelo M. De Marzo, Charles G. Drake
Nature Cancer  ·  19 Jul 2021
Zoila A Lopez-Bujanda, Aleksandar Obradovic, Thomas R Nirschl, Laura Crowley, Rodney Macedo, Alexandros Papachristodoulou, Timothy O’Donnell, Uri Laserson, Jelani C Zarif, Ran Reshef, Tiezheng Yuan, Mithil K Soni, Emmanuel S Antonarakis, Michael C Haffner, H Benjamin Larman, Michael M Shen, Pawel Muranski, Charles G Drake
Journal for ImmunoTherapy of Cancer  ·  30 Jun 2021
Aleksandar Obradovic, Nivedita Chowdhury, Scott M. Haake, Casey Ager, Vinson Wang, Lukas Vlahos, Xinzheng V. Guo, David H. Aggen, W. Kimryn Rathmell, Eric Jonasch, Joyce E. Johnson, Marc Roth, Kathryn E. Beckermann, Brian I. Rini, James McKiernan, Andrea Califano, Charles G. Drake
Cell  ·  27 May 2021
Casey R. Ager, Aleksandar Z. Obradovic, Juan M. Arriaga, Matthew G. Chaimowitz, Andrea Califano, Cory Abate-Shen, Charles G. Drake
Cancer Immunology Research  ·  01 May 2021
Jianing Fu, Julien Zuber, Brittany Shonts, Aleksandar Obradovic, Zicheng Wang, Kristjana Frangaj, Wenzhao Meng, Aaron M. Rosenfeld, Elizabeth E. Waffarn, Peter Liou, Sai-ping Lau, Thomas M. Savage, Suxiao Yang, Kortney Rogers, Nichole M. Danzl, Shilpa Ravella, Prakash Satwani, Alina Iuga, Siu-hong Ho, Adam Griesemer, Yufeng Shen, Eline T. Luning Prak, Mercedes Martinez, Tomoaki Kato, Megan Sykes
Journal of Clinical Investigation  ·  25 Feb 2021
David H. Aggen, Casey R. Ager, Aleksandar Z. Obradovic, Nivedita Chowdhury, Ali Ghasemzadeh, Wendy Mao, Matthew G. Chaimowitz, Zoila A. Lopez-Bujanda, Catherine S. Spina, Jessica E. Hawley, Matthew C. Dallos, Cheng Zhang, Vinson Wang, Hu Li, Xinzheng V. Guo, Charles G. Drake
Clinical Cancer Research  ·  19 Jan 2021

2020

Marlena V. Habal, April M. I. Miller, Samhita Rao, Sijie Lin, Aleksandar Obradovic, Mohsen Khosravi‐Maharlooei, Sarah B. See, Poulomi Roy, Ronzon Shihab, Siu‐Hong Ho, Charles C. Marboe, Yoshifumi Naka, Koji Takeda, Susan Restaino, Arnold Han, Donna Mancini, Michael Givertz, Joren C. Madsen, Megan Sykes, Linda J. Addonizio, Maryjane A. Farr, Emmanuel Zorn
American Journal of Transplantation  ·  05 Oct 2020
Aleksandar Z. Obradovic, Matthew C. Dallos, Marianna L. Zahurak, Alan W. Partin, Edward M. Schaeffer, Ashley E. Ross, Mohamad E. Allaf, Thomas R. Nirschl, David Liu, Carolyn G. Chapman, Tanya O'Neal, Haiyi Cao, Jennifer N. Durham, Gunes Guner, Javier A. Baena-Del Valle, Onur Ertunc, Angelo M. De Marzo, Emmanuel S. Antonarakis, Charles G. Drake
Clinical Cancer Research  ·  01 Jul 2020

2019

Wendy Mao, Ali Ghasemzadeh, Zachary T. Freeman, Aleksandar Obradovic, Matthew G. Chaimowitz, Thomas R. Nirschl, Emily McKiernan, Srinivasan Yegnasubramanian, Charles G. Drake
Journal for ImmunoTherapy of Cancer  ·  01 Oct 2019
Manuel A. Podestà, Christian Binder, Felix Sellberg, Susan DeWolf, Brittany Shonts, Siu‐Hong Ho, Aleksandar Obradovic, Elizabeth Waffarn, Nichole Danzl, David Berglund, Megan Sykes
American Journal of Transplantation  ·  18 Jul 2019
Mohsen Khosravi-Maharlooei, Aleksandar Obradovic, Aditya Misra, Keshav Motwani, Markus Holzl, Howard R. Seay, Susan DeWolf, Grace Nauman, Nichole Danzl, Haowei Li, Siu-hong Ho, Robert Winchester, Yufeng Shen, Todd M. Brusko, Megan Sykes
Journal of Clinical Investigation  ·  28 Mar 2019
Jianing Fu, Julien Zuber, Mercedes Martinez, Brittany Shonts, Aleksandar Obradovic, Hui Wang, Sai-ping Lau, Amy Xia, Elizabeth E. Waffarn, Kristjana Frangaj, Thomas M. Savage, Michael T. Simpson, Suxiao Yang, Xinzheng V. Guo, Michelle Miron, Takashi Senda, Kortney Rogers, Adeeb Rahman, Siu-hong Ho, Yufeng Shen, Adam Griesemer, Donna L. Farber, Tomoaki Kato, Megan Sykes
Cell Stem Cell  ·  07 Feb 2019

2018

Thomas M. Savage, Brittany A. Shonts, Aleksandar Obradovic, Susan Dewolf, Saiping Lau, Julien Zuber, Michael T. Simpson, Erik Berglund, Jianing Fu, Suxiao Yang, Siu-Hong Ho, Qizhi Tang, Laurence A. Turka, Yufeng Shen, Megan Sykes
JCI Insight  ·  01 Nov 2018
Susan DeWolf, Boris Grinshpun, Thomas Savage, Sai Ping Lau, Aleksandar Obradovic, Brittany Shonts, Suxiao Yang, Heather Morris, Julien Zuber, Robert Winchester, Megan Sykes, Yufeng Shen
JCI Insight  ·  09 Aug 2018

2017

B. Sprangers, S. DeWolf, T. M. Savage, T. Morokata, A. Obradovic, S. A. LoCascio, B. Shonts, J. Zuber, S. P. Lau, R. Shah, H. Morris, V. Steshenko, E. Zorn, F. I. Preffer, S. Olek, D. M. Dombkowski, L. A. Turka, R. Colvin, R. Winchester, T. Kawai, M. Sykes
American Journal of Transplantation  ·  01 Mar 2017

2016

Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L. Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
Science Immunology  ·  01 Oct 2016